Blisters will, at some point, afflict most runners. They are not pleasant, they can lead to a decrease in performance and efficiency and, if poorly looked after, are an amazing vehicle for infection. The discomfort of running with a blister and the resulting antalgic gait that we adopt, i.e. changing the way we run because of blisters, can lead to dysfunction and a higher potential for injury. Let’s explore some causes of blisters and some strategies to prevent and treat.